Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BTG2 is an LXXLL-dependent co-repressor for androgen receptor transcriptional activity.

Biochemical and biophysical research communications - 28 Jan 2011

Hu Xu-Dong, Meng Qing-Hui, Xu Jia-Ying, Jiao Yang, Ge Chun-Min, Jacob Asha, Wang Ping, Rosen Eliot M, Fan Saijun

Abstract excerpt

The tumor suppressor gene, BTG2 has been down-regulated in prostate cancer and the ectopic expression of this gene has been shown to inhibit prostate cancer cell growth. Sequence analysis revealed that the BTG2 protein contains two leucine-rich motifs ((20)LxxLL(24) and (92)LxxLL(96)), which are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Proliferation
Share to Gene Expression Regulation, Neoplastic
Share to Immediate-Early Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leucine Zippers

Share to Prostatic Neoplasms

Share to Receptors, Androgen

Share to Repressor Proteins

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 21172304
DOI: 10.1016/j.bbrc.2010.12.064

Genes

BTG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21172304-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

BTG2 is an LXXLL-dependent co-repressor for androgen receptor transcriptional activity.PMID 21172304Read ↗

Crystal structures of human BTG2 and mouse TIS21 involved in suppression of CAF1 deadenylase activity.Semantic proximity Read ↗

The LATS2/KPM Tumor Suppressor Is a Negative Regulator of the Androgen ReceptorSemantic proximity Read ↗

Ligand- and coactivator-mediated transactivation function (AF2) of the androgen receptor ligand-binding domain is inhibited by the cognate hinge region.Semantic proximity Read ↗

Transforming Growth Factor-β-stimulated Clone-22 Is a Member of a Family of Leucine Zipper Proteins That Can Homo- and Heterodimerize and Has Transcriptional Repressor ActivitySemantic proximity Read ↗

Beta-catenin binds to the activation function 2 region of the androgen receptor and modulates the effects of the N-terminal domain and TIF2 on ligand-dependent transcription.Semantic proximity Read ↗

Testicular zinc finger protein recruits histone deacetylase 2 and suppresses the transactivation function and intranuclear foci formation of agonist-bound androgen receptor competitively with TIF2.Semantic proximity Read ↗

Interaction of the human androgen receptor transactivation function with the general transcription factor TFIIFSemantic proximity Read ↗

The interaction between androgen receptor and semenogelin I: a synthetic LxxLL peptide antagonist inhibits the growth of prostate cancer cells.Semantic proximity Read ↗

Tip110, the human immunodeficiency virus type 1 (HIV-1) Tat-interacting protein of 110 kDa as a negative regulator of androgen receptor (AR) transcriptional activation.Semantic proximity Read ↗

Characterization of a novel negative regulator (DOC-2/DAB2) of c-Src in normal prostatic epithelium and cancer.Semantic proximity Read ↗

Tob proteins suppress steroid hormone receptor-mediated transcriptional activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.