Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of protein kinase A on accumulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) in HepG2 cell nuclei.

Proceedings of the National Academy of Sciences of the United States of America - 21 Feb 2006

Citterio Carmen, Jones Heather D, Pacheco-Rodriguez Gustavo, Islam Aminul, Moss Joel, Vaughan Martha

Abstract excerpt

Brefeldin A-inhibited guanine nucleotide-exchange proteins, BIG1 and BIG2, are activators of ADP-ribosylation factor GTPases that are essential for regulating vesicular traffic among intracellular organelles. Biochemical analyses and immunofluorescence microscopy demonstrated BIG1 in nuclei as well as membranes and cytosol of serum-starved HepG2 cells. Within 20 min after addition of 8-Br-cAMP, BIG1 accumulated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 8-Bromo Cyclic Adenosine Monophosphate
Share to Cyclic AMP-Dependent Protein Kinase RIalpha Subunit

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclic AMP-Dependent Protein Kinases

Share to Cytosol

Share to Guanine Nucleotide Exchange Factors

Share to Microtubules

Share to Nocodazole

Share to Nuclear Localization Signals

Source

Open in PubMed Open full text

Identifiers

PMID: 16467138
DOI: 10.1073/pnas.0510571103
PMCID: PMC1413798

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Effect of protein kinase A on accumulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) in HepG2 cell nuclei.PMID 16467138Read ↗

BIG2, a guanine nucleotide exchange factor for ADP-ribosylation factors: its localization to recycling endosomes and implication in the endosome integrity.Semantic proximity Read ↗

Redundant roles of BIG2 and BIG1, guanine-nucleotide exchange factors for ADP-ribosylation factors in membrane traffic between the trans-Golgi network and endosomes.Semantic proximity Read ↗

Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Specific activation of Gsalpha by an NDPK B.Gbetagamma complex in H10 cells.Semantic proximity Read ↗

Phosphorylation of CalDAG-GEFI by protein kinase A prevents Rap1b activation.Semantic proximity Read ↗

BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity.Semantic proximity Read ↗

Cell volume regulation in response to hypotonicity is impaired in HeLa cells expressing a protein kinase Calpha mutant lacking kinase activity.Semantic proximity Read ↗

Proteolytic processing of cGMP-dependent protein kinase I mediates nuclear cGMP signaling in vascular smooth muscle cells.Semantic proximity Read ↗

Phospholamban pentamers attenuate PKA-dependent phosphorylation of monomers.Semantic proximity Read ↗

Myristoylation of cGMP-dependent protein kinase dictates isoform specificity for serotonin transporter regulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.