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Article

Proteolytic processing of cGMP-dependent protein kinase I mediates nuclear cGMP signaling in vascular smooth muscle cells.

Circulation research - 3 Jul 2008

Sugiura Takahiro, Nakanishi Hidehiko, Roberts Jesse D

Abstract excerpt

Cyclic GMP modulates gene expression in vascular smooth muscle cells (SMCs) in part by stimulating cGMP-dependent protein kinase I (PKGI) and the phosphorylation of transcription factors. In some cells, cGMP increases nuclear translocation of PKGI and PKGI-dependent phosphorylation of transcription regulators; however, these observations have been variable, and the mechanisms mediating nuclear PKGI translocation...

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Identifiers

PMID: 18535260
DOI: 10.1161/CIRCRESAHA.108.176321
PMCID: PMC2749497

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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