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Article

Novel Mechanisms of Resistance to Endocrine Therapy: Genomic and Nongenomic Considerations

1 Feb 2006

Abstract excerpt

Selective estrogen receptor (ER) modulators have been the most commonly used neoadjuvant therapy for hormone-dependent breast cancer. However, resistance to endocrine therapy, either inherent or acquired during treatment, presents a major challenge in disease management. The causes of resistance to hormone therapy are not well understood and are the subject of active investigation. It is increasingly clear that...

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PMID: 16467116
DOI: 10.1158/1078-0432.ccr-05-2110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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