Article
A rapid and sensitive enzymatic method for epidermal growth factor receptor mutation screening.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2006
Jänne Pasi A, Borras Ana M, Kuang Yanan, Rogers Andrew M, Joshi Victoria A, Liyanage Hema, Lindeman Neal, Lee Jeffrey C, Halmos Balazs, Maher Elizabeth A, Distel Robert J, Meyerson Matthew, Johnson Bruce E
Abstract excerpt
PURPOSE: Mutations in the epidermal growth factor receptor (EGFR) are associated with clinical and radiographic responses to EGFR tyrosine kinase inhibitors gefitinib and erlotinib. Currently available methods of EGFR mutation detection rely on direct DNA sequencing, which requires isolation of DNA from a relatively pure population of tumor cells, cannot be done on small diagnostic specimens, and lack...
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