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Article

Cholesterol substrate pools and steroid hormone levels are normal in the face of mutational inactivation of NPC1 protein.

Journal of lipid research - 1 May 2006

Xie Chonglun, Richardson James A, Turley Stephen D, Dietschy John M

Abstract excerpt

Mutational inactivation of NPC1 largely blocks the movement of LDL-derived cholesterol from the lysosome to the metabolically active, cytosolic pool of sterol that is the substrate for steroid hormone production. Such a block might, in theory, lead to deficiencies in circulating levels of testosterone, progesterone, and corticosterone. However, there are at least two other sources for cellular cholesterol, de...

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Share to Adrenal Glands
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lipoproteins, HDL

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Share to Scavenger Receptors, Class B

Source

Identifiers

PMID: 16461760
DOI: 10.1194/jlr.M500534-JLR200

Genes

NPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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