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Article

The role and regulation of the Niemann-Pick C1 gene in adrenal steroidogenesis.

Endocrine research - 1 Nov 2002

Gévry Nicolas Y, Murphy Bruce D

Abstract excerpt

The Niemann-Pick C-1 (NPC-1) gene codes for an intracellular membrane glycoprotein that processes low density lipoprotein (LDL)-imported cholesterol. Its absence is characterized by pathologic accumulation of cholesterol in endosomes and lysosomes. Niemann-Pick C-1 is involved in steroidogenesis in the adrenal, ovary, testis, and placenta. We investigated adrenal morphology of the BALB/c NPC-1(-/-) mutant mouse....

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PMID: 12530642
DOI: 10.1081/erc-120016815

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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