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Article

Dysregulation of testicular cholesterol metabolism following spontaneous mutation of the niemann-pick c1 gene in mice.

Biology of reproduction - 1 Aug 2014

Akpovi Casimir D, Murphy Bruce D, Erickson Robert P, Pelletier R-Marc

Abstract excerpt

The Niemann-Pick-type C1 (Npc1) protein mobilizes LDL-derived cholesterol from lysosomes. Npc1 deficiency disease is a panethnic autosomal recessive disorder of intracellular cholesterol trafficking, leading to accumulation of cholesterol in endosomes/lysosomes. This report assesses the effects of a spontaneous inactivating mutation of the Npc1 gene on spermatogenesis and cholesterol homeostasis in mice. We...

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Source

Identifiers

PMID: 25009206
DOI: 10.1095/biolreprod.114.119412

Genes

ABCA1
ACAT1
ACAT2

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