Article
CCR5 and CCR2 gene polymorphisms in hypertensive patients.
British journal of biomedical science - 1 Jan 2003
Mettimano M, Specchia M L, Ianni A, Arzani D, Ricciardi G, Savi L, Romano-Spica V
Abstract excerpt
Essential hypertension is a complex trait under polygenic control. Evidences suggests immune system involvement during pathogenesis. CC-chemokine receptor (CCR)5 and CCR2 are characterised by gene polymorphism. Variant alleles are derived from a deletion in the CCR5 gene (CCR5delta32) and a substitution mutation at the CCR2 locus (CCR264I). CCR polymorphic forms have been studied extensively as invasion cofactors...
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