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Article

Langerhans-type dendritic cells genetically modified to express full-length antigen optimally stimulate CTLs in a CD4-dependent manner.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2006

Yuan Jianda, Latouche Jean-Baptiste, Hodges Joanna, Houghton Alan N, Heller Glenn, Sadelain Michel, Riviere Isabelle, Young James W

Abstract excerpt

Oncoretroviral vectors encoding either full-length Ag or a corresponding immunodominant peptide were expressed in Langerhans-type dendritic cells (LCs) differentiated from CD34(+) progenitors. We used human CMV as a model Ag restricted by HLA-A*0201 to define parameters for eventual expression of cancer Ags by LCs for active immunization against tumors. Stimulation by CMVpp65(495-503)-pulsed LCs,...

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Share to Antigens, CD34
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16455993
DOI: 10.4049/jimmunol.176.4.2357

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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