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Article

IFN-gamma enables cross-presentation of exogenous protein antigen in human Langerhans cells by potentiating maturation.

Proceedings of the National Academy of Sciences of the United States of America - 5 Oct 2004

Matsuo Mitsutoshi, Nagata Yasuhiro, Sato Eiichi, Atanackovic Djordje, Valmori Danila, Chen Yao-Tseng, Ritter Gerd, Mellman Ira, Old Lloyd J, Gnjatic Sacha

Abstract excerpt

We compared monocyte-derived dendritic cells and transforming growth factor-beta1-induced Langerhans-like cells (LCs) for their capacity to cross-present exogenous NY-ESO-1 protein/antibody immune complexes to an NY-ESO-1-specific CD8+ T cell clone. In contrast to dendritic cells, LCs were not able to cross-present NY-ESO-1 to the T cell clone constitutively but did so after treatment with IFN-gamma. Remarkably,...

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Identifiers

PMID: 15383663
DOI: 10.1073/pnas.0405947101
PMCID: PMC521945

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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