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Lentivirally transduced dendritic cells as a tool for cancer immunotherapy

23 Apr 2003

Abstract excerpt

BACKGROUND: Dendritic cells (DC) are the professional antigen-presenting cells of the immune system, fully equipped to prime naive T cells and thus essential components for cancer immunotherapy. METHODS: We tested the influence of several elements (cPPT, trip, WPRE, SIN) on the transduction efficiency of human DC. Human and murine DC were transduced with tNGFR-encoding lentiviruses to assess the effect of...

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PMID: 12898635
DOI: 10.1002/jgm.400

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