Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dendritic Cells Loaded With mRNA Encoding Full-length Tumor Antigens Prime CD4+ and CD8+ T Cells in Melanoma Patients

28 Feb 2012

Abstract excerpt

It is generally thought that dendritic cells (DCs) loaded with full-length tumor antigen could improve immunotherapy by stimulating broad T-cell responses and by allowing treatment irrespective of the patient's human leukocyte antigen (HLA) type. To investigate this, we determined the specificity of T cells from melanoma patients treated with DCs loaded with mRNA encoding a full-length tumor antigen fused to a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to CAR-T cell therapy research
Share to Immunotherapy and Immune Responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22371843
DOI: 10.1038/mt.2012.11

Provenance

PubMed metadata and Literature Corpus relationships.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dendritic Cells Loaded With mRNA Encoding Full-length Tumor Antigens Prime CD4+ and CD8+ T Cells in Melanoma PatientsPMID 22371843Read ↗

Dendritic Cell Strategies for Eliciting Mutation-Derived Tumor Antigen Responses in Patients.Semantic proximity Read ↗

Cancer immunotherapy. A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells.Semantic proximity Read ↗

A synthetic DNA template for fast manufacturing of versatile single epitope mRNASemantic proximity Read ↗

Restoring tumor immunogenicity with dendritic cell reprogrammingSemantic proximity Read ↗

Rewiring dendritic cell function with CLEC9A and DEC205-based chimeric antigen receptorsSemantic proximity Read ↗

Antigen-specificity and DTIC before peptide-vaccination differently shape immune-checkpoint expression pattern, anti-tumor functionality and TCR repertoire in melanoma patientsSemantic proximity Read ↗

Spliced peptides and cytokine driven changes in the immunopeptidome of melanomaSemantic proximity Read ↗

Melanoma antigens recognised by CD8+ and CD4+ T cells.Semantic proximity Read ↗

Dendritic cells pulsed with RNA encoding allogeneic MHC and antigen induce T cells with superior antitumor activity and higher TCR functional aviditySemantic proximity Read ↗

Cancer immunotherapy with mRNA‐transfected dendritic cellsSemantic proximity Read ↗

Repurposed endogenous virus-like vesicles mediate dendritic cell long-range antigen presentation and T cell activation for enhanced cancer vaccinationSemantic proximity Read ↗

A cancer immunotherapy modality based on dendritic cell reprogramming <i>in vivo</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.