Article
A panel of artificial APCs expressing prevalent HLA alleles permits generation of cytotoxic T cells specific for both dominant and subdominant viral epitopes for adoptive therapy.
Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2009
Hasan Aisha N, Kollen Wouter J, Trivedi Deepa, Selvakumar Annamalai, Dupont Bo, Sadelain Michel, O'Reilly Richard J
Abstract excerpt
Adoptive transfer of virus-specific T cells can treat infections complicating allogeneic hematopoietic cell transplants. However, autologous APCs are often limited in supply. In this study, we describe a panel of artificial APCs (AAPCs) consisting of murine 3T3 cells transduced to express human B7.1, ICAM-1, and LFA-3 that each stably express one of a series of six common HLA class I alleles. In comparative...
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