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Article

Shared blood and muscle CD8+ T-cell expansions in inclusion body myositis

2 Feb 2006

Abstract excerpt

Inclusion body myositis (IBM) is the most frequent inflammatory myopathy over the age of fifty. Pathological findings suggest that two processes may contribute to IBM pathogenesis: a primary degenerative process affecting muscle fibre and/or an autoimmune process mediated by major histocompatibility complex (MHC) class-I-restricted cytotoxic CD8+ T cells. Previous studies have demonstrated that...

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Share to Inflammatory Myopathies and Dermatomyositis
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PMID: 16455793
DOI: 10.1093/brain/awl020

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