Article
Inflammatory, immune, and viral aspects of inclusion-body myositis.
Neurology - 24 Jan 2006
Dalakas Marinos C
Abstract excerpt
Muscle biopsies from patients with sporadic inclusion-body myositis (sIBM) consistently demonstrate that the inflammatory T cells almost invariably invade intact (not vacuolated) fibers, whereas the vacuolated fibers are rarely invaded by T cells. This indicates two concurrently ongoing processes, an autoimmune mediated by cytotoxic T cells and a degenerative manifested by the vacuolated muscle fibers and...
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