Article
Oligoclonal expansion of circulating and tissue-infiltrating CD8+ T cells with killer/effector phenotypes in juvenile dermatomyositis syndrome.
Clinical and experimental immunology - 1 Jul 2004
Mizuno K, Yachie A, Nagaoki S, Wada H, Okada K, Kawachi M, Toma T, Konno A, Ohta K, Kasahara Y, Koizumi S
Abstract excerpt
Although triggering by infectious agents and abnormal immune responses may play some role in the pathogenesis of juvenile dermatomyositis syndrome (JDMS), the precise mechanism of muscle destruction and vascular damage is largely unknown. In this study, we tried to elucidate the role of cytotoxic T cells in two patients with JDMS, who were diagnosed based on the characteristic symptoms, laboratory data, MRI...
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