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Article

Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.

Nature cell biology - 1 Nov 2009

da Costa Cristine Alves, Sunyach Claire, Giaime Emilie, West Andrew, Corti Olga, Brice Alexis, Safe Stephen, Abou-Sleiman Patrick M, Wood Nicholas W, Takahashi Hitoshi, Goldberg Mathew S, Shen Jie, Checler Frédéric

Abstract excerpt

Mutations of the ubiquitin ligase parkin account for most autosomal recessive forms of juvenile Parkinson's disease (AR-JP). Several studies have suggested that parkin possesses DNA-binding and transcriptional activity. We report here that parkin is a p53 transcriptional repressor. First, parkin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19801972
DOI: 10.1038/ncb1981
PMCID: PMC2952934

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19801972-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.PMID 19801972Read ↗

Parkin: much more than a simple ubiquitin ligase.Semantic proximity Read ↗

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N-myc Regulates Parkin ExpressionSemantic proximity Read ↗

CHIP Is Associated with Parkin, a Gene Responsible for Familial Parkinson's Disease, and Enhances Its Ubiquitin Ligase ActivitySemantic proximity Read ↗

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Structure of parkin reveals mechanisms for ubiquitin ligase activation.Semantic proximity Read ↗

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