Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of Parkin on methamphetamine‐induced α‐synuclein degradation dysfunction in vitro and in vivo

21 Feb 2020

Abstract excerpt

INTRODUCTION: Methamphetamine (METH) is a psychostimulant drug with complicated neurotoxicity, and abuse of METH is very common. Studies have shown that METH exposure causes alpha-synuclein (α-syn) accumulation. However, the mechanism of α-syn accumulation has not been determined. METHODS: In this study, we established cell and animal models of METH intoxication to evaluate how METH affects α-syn expression. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neurotransmitter Receptor Influence on Behavior
Share to Parkinson's Disease Mechanisms and Treatments
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32086884
DOI: 10.1002/brb3.1574

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of Parkin on methamphetamine‐induced α‐synuclein degradation dysfunction in vitro and in vivoPMID 32086884Read ↗

The effect of α-synuclein and Tau in methamphetamine induced neurotoxicity in vivo and in vitroSemantic proximity Read ↗

Methamphetamine induced neurotoxic diseases, molecular mechanism, and current treatment strategiesSemantic proximity Read ↗

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons.Semantic proximity Read ↗

Molecular mechanisms of programmed cell death in methamphetamine-induced neuronal damageSemantic proximity Read ↗

Differential roles of proteasome and autophagy in α-synuclein and E46K oligomer clearance: insight into the modulatory effects of the dopamine metabolite DOPAC.Semantic proximity Read ↗

Parkin protects against tyrosinase-mediated dopamine neurotoxicity by suppressing stress-activated protein kinase pathways.Semantic proximity Read ↗

Neurotoxic Methamphetamine Doses Alter CDCel-1 Levels and Its Interaction with Vesicular Monoamine Transporter-2 in Rat StriatumSemantic proximity Read ↗

Parkin-deficient mice are not more sensitive to 6-hydroxydopamine or methamphetamine neurotoxicitySemantic proximity Read ↗

Involvement of mortalin/GRP75/mthsp70 in the mitochondrial impairments induced by A53T mutant α-synuclein.Semantic proximity Read ↗

Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer modelSemantic proximity Read ↗

Similarities between Methamphetamine Toxicity and Proteasome InhibitionSemantic proximity Read ↗

Neuroprotection of α-synuclein under acute and chronic rotenone and maneb treatment is abolished by its familial Parkinson's disease mutations A30P, A53T and E46K.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.