Article
Genetic analyses reveal structured HIV-1 populations in serially sampled T lymphocytes of patients receiving HAART.
Virology - 25 Apr 2006
Potter Simon J, Lemey Philippe, Dyer Wayne B, Sullivan John S, Chew Choo Beng, Vandamme Anne-Mieke, Dwyer Dominic E, Saksena Nitin K
Abstract excerpt
HIV-1 infection and compartmentalization in diverse leukocyte targets significantly contribute to viral persistence during suppressive highly active antiretroviral therapy (HAART). Longitudinal analyses were performed on envelope sequences of HIV-1 populations from plasma, CD4+ and CD8+ T lymphocytes in 14 patients receiving HAART and 1 therapy-naive individual. Phylogenetic reconstructions and analysis of...
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