Article
Agouti antagonism of melanocortin binding and action in the B16F10 murine melanoma cell line.
Biochemistry - 22 Aug 1995
Blanchard S G, Harris C O, Ittoop O R, Nichols J S, Parks D J, Truesdale A T, Wilkison W O
Abstract excerpt
Several dominant mutations at the murine agouti locus result in the expression of a number of phenotypic changes, including a predominantly yellow coat color, obesity, and hyperinsulinemia. The mutants exhibit ectopic overexpression of normal agouti protein, suggesting that agouti regulates coat...
Topics
- 1-Methyl-3-isobutylxanthine
- Adenylyl Cyclases
- Agouti Signaling Protein
- Animals
- Binding, Competitive
- Cyclic AMP
- Intercellular Signaling Peptides and Proteins
- Iodine Radioisotopes
- Kinetics
- Melanoma, Experimental
- Mice
- Mutation
- Proteins
- Receptors, Pituitary Hormone
- Tumor Cells, Cultured
- alpha-MSH