Article
DNA methylation in small lung adenocarcinoma with bronchioloalveolar carcinoma components.
Lung cancer (Amsterdam, Netherlands) - 1 Sept 2009
Kubo Takafumi, Yamamoto Hiromasa, Ichimura Koichi, Jida Masaru, Hayashi Tatsuro, Otani Hiroki, Tsukuda Kazunori, Sano Yoshifumi, Kiura Katsuyuki, Toyooka Shinichi
Abstract excerpt
We examined the methylation status in 100 specimens of lung adenocarcinomas measuring 2cm or less and with bronchioloalveolar carcinoma (BAC) components (Noguchi types A-C) and then compared the methylation status between noninvasive tumors (Noguchi type A or B) and invasive tumors (Noguchi type C). Methylation-specific PCR was used to determine the methylation statuses of p16(INK4a), RASSF1A, CDH13, RARbeta, and...
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