Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations in the extra sex combs and Enhancer of Polycomb genes increase homologous recombination in somatic cells of Drosophila melanogaster.

Genetics - 1 Apr 2006

Holmes Angela M, Weedmark Kelly A, Gloor Gregory B

Abstract excerpt

We found that heterozygous mutant alleles of E(Pc) and esc increased homologous recombination from an allelic template in somatic cells in a P-element-induced double-strand break repair assay. Flies heterozygous for mutant alleles of these genes showed increased genome stability and decreased levels of apoptosis in imaginal discs and a concomitant increase in survival following ionizing radiation. We propose that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone Deacetylase 1

Share to Histone Deacetylases

Share to Histone-Lysine N-Methyltransferase

Share to Polycomb Repressive Complex 1

Share to Polycomb Repressive Complex 2

Share to Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 16452150
DOI: 10.1534/genetics.105.042473
PMCID: PMC1456408

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in the extra sex combs and Enhancer of Polycomb genes increase homologous recombination in somatic cells of Drosophila melanogaster.PMID 16452150Read ↗

Interactions of polyhomeotic with Polycomb group genes of Drosophila melanogaster.Semantic proximity Read ↗

Screen for enhancers of Polycomb and Polycomblike in Drosophila melanogaster.Semantic proximity Read ↗

Genetic interactions and dosage effects of Polycomb group genes of Drosophila.Semantic proximity Read ↗

Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance.Semantic proximity Read ↗

Dominant modifiers of the polyhomeotic extra-sex-combs phenotype induced by marked P element insertional mutagenesis in Drosophila.Semantic proximity Read ↗

spn-A/rad51 mutant exhibits enhanced genomic damage, cell death and low temperature sensitivity in somatic tissues.Semantic proximity Read ↗

Persistent replicative stress alters polycomb phenotypes and tissue homeostasis in Drosophila melanogaster.Semantic proximity Read ↗

Analysis of a polycomb group protein defines regions that link repressive activity on nucleosomal templates to in vivo function.Semantic proximity Read ↗

The extra sex combs product contains WD40 repeats and its time of action implies a role distinct from other Polycomb group products.Semantic proximity Read ↗

Directed overexpression of suppressor 2 of zeste and Posterior Sex Combs results in bristle abnormalities in Drosophila melanogaster.Semantic proximity Read ↗

The Drosophila Polycomb group gene Sex combs extra encodes the ortholog of mammalian Ring1 proteins.Semantic proximity Read ↗

A 1-megadalton ESC/E(Z) complex from Drosophila that contains polycomblike and RPD3.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.