Article
Analysis of alcohol dependence phenotype in the COGA families using covariates to detect linkage.
BMC genetics - 30 Dec 2005
Reck Brian H, Mukhopadhyay Nandita, Tsai Hui-Ju, Weeks Daniel E
Abstract excerpt
Linkage analysis methods that incorporate etiological heterogeneity of complex diseases are likely to demonstrate greater power than traditional linkage analysis methods. Several such methods use covariates to discriminate between linked and unlinked pedigrees with respect to a certain disease locus. Here we apply several such methods including two mixture models, ordered subset analysis, and a conditional...
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