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Article

Familial and metachronous malignant lymphoma: absence of constitutional p53 mutations.

American journal of hematology - 1 Nov 1999

Pötzsch C, Schaefer H E, Lübbert M

Abstract excerpt

Familial and metachronous aggregations of malignant lymphoma are well-documented, but the molecular basis of a predisposition for development of lymphoma is as yet unclear. Malignant lymphomas have been described as part of the spectrum of neoplasias in Li-Fraumeni syndrome (LFS), which is associated with constitutional mutations of p53. However, p53 germline mutations have also, albeit less frequently, been...

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Identifiers

PMID: 10539880
DOI: 10.1002/(sici)1096-8652(199911)62:3<144::aid-ajh3>3.0.co;2-q

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