Familial and metachronous malignant lymphoma: absence of constitutional p53 mutations.

doi:10.1002/(sici)1096-8652(199911)62:3<144::aid-ajh3>3.0.co;2-q

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Article

Familial and metachronous malignant lymphoma: absence of constitutional p53 mutations.

American journal of hematology - 1 Nov 1999

Pötzsch C, Schaefer H E, Lübbert M

Abstract excerpt

Familial and metachronous aggregations of malignant lymphoma are well-documented, but the molecular basis of a predisposition for development of lymphoma is as yet unclear. Malignant lymphomas have been described as part of the spectrum of neoplasias in Li-Fraumeni syndrome (LFS), which is associated with constitutional mutations of p53. However, p53 germline mutations have also, albeit less frequently, been...

Topics

Adult
Aged
Child, Preschool
DNA
Female
Genes, p53
Humans
Lymphoma
Male
Middle Aged
Mutation
Neoplasms, Second Primary
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational

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Open in PubMed

Identifiers

PMID: 10539880
DOI: 10.1002/(sici)1096-8652(199911)62:3<144::aid-ajh3>3.0.co;2-q

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