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Article

Phosphorylation of NF-kappaB1/p105 by oncoprotein kinase Tpl2: implications for a novel mechanism of Tpl2 regulation.

Biochimica et biophysica acta - 1 Feb 2006

Babu Geetha R, Jin Wei, Norman Lourdes, Waterfield Michael, Chang Mikyoung, Wu Xuefeng, Zhang Minying, Sun Shao-Cong

Abstract excerpt

The oncoprotein kinase Tpl2 plays an essential role in macrophage activation by the bacterial component lipopolysaccharide (LPS). In response to LPS stimulation, Tpl2 phosphorylates a downstream kinase, MEK1, leading to the activation of ERK signaling pathway. Recent studies demonstrate that the NF-kappaB1 precursor protein p105 functions as an inhibitor of Tpl2 and that the LPS-stimulated Tpl2 activation...

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Identifiers

PMID: 16448710
DOI: 10.1016/j.bbamcr.2005.12.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Phosphorylation of NF-kappaB1/p105 by oncoprotein kinase Tpl2: implications for a novel mechanism of Tpl2 regulation.PMID 16448710Read ↗

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