Mutations associated with carcinomas arising from pleomorphic adenomas of the salivary glands.

doi:10.1016/s0046-8177(96)90449-9

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Article

Mutations associated with carcinomas arising from pleomorphic adenomas of the salivary glands.

Human pathology - 1 Aug 1996

Yamamoto Y, Kishimoto Y, Virmani A K, Smith A, Vuitch F, Albores-Saavedra J, Gazdar A F

Abstract excerpt

Pleomorphic adenoma (PA) is the most common benign tumor of salivary glands. Carcinomas in pleomorphic adenomas (CPAs) may arise by malignant transformation of the epithelial components of PAs. Occasionally, transitional zones containing cells with histological features intermediate between those of the benign PA and carcinomatous components of CPA are identified. After careful microdissection of archival...

Topics

Adenocarcinoma
Adenoma, Pleomorphic
Carcinoma
Chromosomes, Human, Pair 5
Genes, Retinoblastoma
Genes, p53
Heterozygote
Humans
Mutation
Salivary Gland Neoplasms

Source

Open in PubMed

Identifiers

PMID: 8760010
DOI: 10.1016/s0046-8177(96)90449-9

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