Article
Polymorphisms of the TUB gene are associated with body composition and eating behavior in middle-aged women.
PloS one - 9 Jan 2008
van Vliet-Ostaptchouk Jana V, Onland-Moret N Charlotte, Shiri-Sverdlov Ronit, van Gorp Patrick J J, Custers Anne, Peeters Petra H M, Wijmenga Cisca, Hofker Marten H, van der Schouw Yvonne T
Abstract excerpt
BACKGROUND: The TUB gene, encoding an evolutionary conserved protein, is highly expressed in the hypothalamus and might act as a transcription factor. Mutations in TUB cause late-onset obesity, insulin-resistance and neurosensory deficits in mice. An association of common variants in the TUB gene with body weight in humans has been reported. METHODS/FINDINGS: The aim was to investigate the relationship of single...
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