Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hereditary lactate dehydrogenase A-subunit deficiency as cause of early postimplantation death of homozygotes in Mus musculus.

Genetics - 1 Jun 1992

Merkle S, Favor J, Graw J, Hornhardt S, Pretsch W

Abstract excerpt

Two ethylnitrosourea-induced heterozygous mouse mutants with approximately 58 and 50% of wild-type lactate dehydrogenase (LDH) activity and a gamma-ray-induced heterozygous mutant with 50% of wild-type LDH activity in blood, liver and spleen (expressing predominantly the Ldh-1 gene) were recovered in mutagenicity experiments following spermatogonial treatment. Physiological and genetic studies revealed no...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Genes
Share to Genes, Lethal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Homozygote

Share to Mice, Mutant Strains

Share to Mutagenesis

Share to Pregnancy

Source

Open in PubMed Open full text

Identifiers

PMID: 1644279
DOI: 10.1093/genetics/131.2.413
PMCID: PMC1205015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hereditary lactate dehydrogenase A-subunit deficiency as cause of early postimplantation death of homozygotes in Mus musculus.PMID 1644279Read ↗

Characterization of two electrophoretic lactate dehydrogenase-A mutants in Mus musculus.Semantic proximity Read ↗

Molecular, genetic and biochemical characterization of lactate dehydrogenase-A enzyme activity mutations in Mus musculus.Semantic proximity Read ↗

A mutation affecting the lactate dehydrogenase locus Ldh-1 in the mouse. II. Mechanism of the LDH-A deficiency associated with hemolytic anemia.Semantic proximity Read ↗

Genetic, biochemical, and molecular characterization of nine glyceraldehyde-3-phosphate dehydrogenase mutants with reduced enzyme activity in Mus musculus.Semantic proximity Read ↗

Molecular analysis of four lactate dehydrogenase-A mutants in the mouse.Semantic proximity Read ↗

A glucosephosphate isomerase (GPI) null mutation in Mus musculus: evidence that anaerobic glycolysis is the predominant energy delivering pathway in early post-implantation embryos.Semantic proximity Read ↗

Detection of Loss of Heterozygosity in Tk-Deficient Mutants from L5178Y Tk+/--3.7.2C Mouse Lymphoma Cells.Semantic proximity Read ↗

Molecular characterization of genetic mutation in human lactate dehydrogenase-A (M) deficiency.Semantic proximity Read ↗

Enzyme-activity mutants in Mus musculus. I. Phenotypic description and genetic characterization of ethylnitrosourea-induced mutations.Semantic proximity Read ↗

Glucose phosphate isomerase enzyme-activity mutants in Mus musculus: genetical and biochemical characterization.Semantic proximity Read ↗

Maternal enzyme masks the phenotype of mouse embryos lacking dihydrolipoamide dehydrogenase.Semantic proximity Read ↗

Analysis of mouse hemoglobin alpha-chain locus mutation induced by N-ethyl-N-nitrosourea.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.