Hereditary lactate dehydrogenase A-subunit deficiency as cause of early postimplantation death of homozygotes in Mus musculus.

doi:10.1093/genetics/131.2.413

Back to search

Article

Hereditary lactate dehydrogenase A-subunit deficiency as cause of early postimplantation death of homozygotes in Mus musculus.

Genetics - 1 Jun 1992

Merkle S, Favor J, Graw J, Hornhardt S, Pretsch W

Abstract excerpt

Two ethylnitrosourea-induced heterozygous mouse mutants with approximately 58 and 50% of wild-type lactate dehydrogenase (LDH) activity and a gamma-ray-induced heterozygous mutant with 50% of wild-type LDH activity in blood, liver and spleen (expressing predominantly the Ldh-1 gene) were recovere...

Topics

Alleles
Animals
Energy Metabolism
Female
Fetal Death
Genes
Genes, Lethal
Homozygote
L-Lactate Dehydrogenase
Litter Size
Male
Mice
Mice, Mutant Strains
Mutagenesis
Organ Specificity
Pregnancy

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.