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Article

Molecular, genetic and biochemical characterization of lactate dehydrogenase-A enzyme activity mutations in Mus musculus.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Feb 1998

Pretsch W, Chatterjee B, Favor J, Merkle S, Sandulache R

Abstract excerpt

Four independent heterozygous lactate dehydrogenase (LDH) mutations with approximately 60% of wild-type enzyme activity in whole blood have been recovered. The mutant line Ldh1a2Neu proved to be homozygous lethal, whereas for the three lines Ldh1a7Neu, Ldh1a11Neu, and Ldh1a12Neu homozygous mutants with about 20% residual activity occurred in the progeny of heterozygous inter se matings. However, the number of...

Topics

Amino Acid Sequence
Animals
Base Sequence
Codon
Crosses, Genetic
Electrophoresis, Polyacrylamide Gel
Female
Gene Conversion
Heterozygote
L-Lactate Dehydrogenase
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred C3H

Molecular Sequence Data

Mutation

Source

Identifiers

PMID: 9457676
DOI: 10.1007/s003359900705

Genes

LDHA

Provenance

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