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Article

A mutation affecting the lactate dehydrogenase locus Ldh-1 in the mouse. II. Mechanism of the LDH-A deficiency associated with hemolytic anemia.

Genetics - 1 Sept 1993

Pretsch W, Merkle S, Favor J, Werner T

Abstract excerpt

A procarbazine hydrochloride-induced mutation at the Ldh-1 structural locus encoding the A subunit of lactate dehydrogenase (LDH) was used to study the molecular and metabolic basis of severe hemolytic anemia due to LDH-A deficiency in the mouse. The mutant allele designated Ldh-1a-m1Neu codes for an enzyme that as homotetramer differs from the wild-type enzyme by a marked instability, acidic shift of the pH...

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Identifiers

PMID: 8224816
DOI: 10.1093/genetics/135.1.161
PMCID: PMC1205615

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