A mutation affecting the lactate dehydrogenase locus Ldh-1 in the mouse. II. Mechanism of the LDH-A deficiency associated with hemolytic anemia.

doi:10.1093/genetics/135.1.161

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Article

A mutation affecting the lactate dehydrogenase locus Ldh-1 in the mouse. II. Mechanism of the LDH-A deficiency associated with hemolytic anemia.

Genetics - 1 Sept 1993

Pretsch W, Merkle S, Favor J, Werner T

Abstract excerpt

A procarbazine hydrochloride-induced mutation at the Ldh-1 structural locus encoding the A subunit of lactate dehydrogenase (LDH) was used to study the molecular and metabolic basis of severe hemolytic anemia due to LDH-A deficiency in the mouse. The mutant allele designated Ldh-1a-m1Neu codes fo...

Topics

Anemia, Hemolytic
Animals
Bilirubin
Body Weight
Erythrocytes
Female
Glycolysis
Heterozygote
Homozygote
L-Lactate Dehydrogenase
Liver
Male
Mice
Mice, Inbred C3H
Mutation
Spleen

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