Article
Reversible modulation of SIRT1 activity in a mouse strain.
PloS one - 1 Jan 2017
Clark-Knowles Katherine V, He Xiaohong, Jardine Karen, Coulombe Josée, Dewar-Darch Danielle, Caron Annabelle Z, Gray Douglas A, McBurney Michael W
Abstract excerpt
The SIRT1 protein deacetylase is reported to have a remarkably wide spectrum of biological functions affecting such varied processes as aging, cancer, metabolism, neurodegeneration and immunity. However, the SIRT1 literature is also full of contradictions. To help establish the role(s) of SIRT1 in these and other biological processes, we set out to create a mouse in which the SIRT1 activity could be toggled...
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