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Article

The Polymorphism rs2968 of LSS Gene Confers Susceptibility to Age-Related Cataract.

DNA and cell biology - 1 Nov 2020

Zou Xi, Wang Hao, Zhou Dong, Liu Zhinan, Wang Yong, Deng Guohua, Guan Huaijin

Abstract excerpt

Research showed that lanosterol can decrease protein aggregation in lens and reduce cataract formation. Lanosterol synthase (LSS) and 3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) are the limiting enzymes in the process of synthesis of lanosterol. We demonstrate to investigate the association between functional single-nucleotide polymorphisms (SNPs) of LSS and HMGCR genes and age-related cataract (ARC)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32877255
DOI: 10.1089/dna.2020.5872

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