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Article

Increases of efficacy as vaccine against Brucella abortus infection in mice by simultaneous inoculation with avirulent smooth bvrS/bvrR and rough wbkA mutants.

Vaccine - 5 Apr 2006

Grilló María Jesús, Manterola Lorea, de Miguel María Jesús, Muñoz Pilar María, Blasco José María, Moriyón Ignacio, López-Goñi Ignacio

Abstract excerpt

The Brucella abortus S19 and RB51 strains are the most widely used live vaccines against bovine brucellosis. However, both can induce abortion and milk excretion, S19 vaccination interferes in serological tests, and RB51 is less effective. We have shown previously that a rough wbkAB. abortus mutant is attenuated and a better vaccine than RB51 in BALB/c mice, and that mutants in the two-component regulatory system...

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Source

Identifiers

PMID: 16439039
DOI: 10.1016/j.vaccine.2005.12.038

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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