Article
Enhanced efficacy of recombinant Brucella abortus RB51 vaccines against B. melitensis infection in mice.
Veterinary microbiology - 8 Sept 2004
Vemulapalli Ramesh, Contreras Andrea, Sanakkayala Neelima, Sriranganathan Nammalwar, Boyle Stephen M, Schurig Gerhardt G
Abstract excerpt
Brucella abortus strain RB51 is an attenuated rough strain, currently being used as the official live vaccine for bovine brucellosis in the USA and several other countries. In strain RB51, the wboA gene, encoding a glycosyltransferase required for the O-side chain synthesis, is disrupted by an IS711 element. Recently, we have demonstrated that strain RB51WboA, RB51 complemented with a functional wboA gene,...
Topics
- Animals
- Bacterial Vaccines
- Brucella Vaccine
- Brucella abortus
- Brucella melitensis
- Brucellosis
- Cattle
- Genes, Bacterial
- Glycosyltransferases
- Interferon-gamma
- Mice
- O Antigens
- Phenotype
- Recombinant Proteins
- Serologic Tests
- Superoxide Dismutase
- Treatment Outcome
- Vaccines, Attenuated