Article
Common pattern of unusual chromosome abnormalities in hereditary papillary renal carcinoma.
Cancer genetics and cytogenetics - 15 Jan 2006
Prat Esther, Bernués Marta, Del Rey Javier, Camps Jordi, Ponsa Immaculada, Algaba Ferran, Egozcue Josep, Caballín Maria Rosa, Gelabert Antoni, Miró Rosa
Abstract excerpt
In this study, we summarized cytogenetic and comparative genomic hybridization (CGH) results, mutation analysis of the MET gene, and immunohistochemistry results of tumors from three patients in the same family who were affected by hereditary papillary renal carcinoma (HPRC). All three patients showed germline mutations in the tyrosine kinase domain of the MET proto-oncogene, and developed bilateral and multiple...
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