Article
Patterns of specific genomic alterations associated with poor prognosis in high-grade renal cell carcinomas.
Cancer genetics and cytogenetics - 15 Oct 2001
Glukhova L, Angevin E, Lavialle C, Cadot B, Terrier-Lacombe M J, Perbal B, Bernheim A, Goguel A F
Abstract excerpt
A series of 13 sporadic renal cell carcinomas was analyzed for the specific chromosome rearrangements after serial xenografting into immunodeficient mice. Seven tumors displayed genetic traits of the conventional subtype and 5 showed genetic features of the papillary subtype. In all the xenografted conventional tumors, we observed loss of 3p, as well as loss of the 9p21 region and of the long arm of chromosome...
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