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Article

Duplication and overexpression of the mutant allele of the MET proto-oncogene in multiple hereditary papillary renal cell tumours.

Oncogene - 13 Aug 1998

Fischer J, Palmedo G, von Knobloch R, Bugert P, Prayer-Galetti T, Pagano F, Kovacs G

Abstract excerpt

Previous karyotyping showed a combined trisomy of chromosome 7 and 17 in sporadic and hereditary papillary renal cell tumours (RCT). A recent molecular analysis revealed a mutation in the MET tyrosine kinase (chromosome 7q31) in the germline of four out of seven families with hereditary papillary...

Topics

Adenoma
Alleles
Base Sequence
Carcinoma, Renal Cell
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 7
Gene Dosage
Germ-Line Mutation
Humans
Kidney Neoplasms
Microsatellite Repeats
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multigene Family

Mutation

Proto-Oncogene Mas

Proto-Oncogene Proteins c-met

Sequence Analysis, DNA

Source

Identifiers

PMID: 9715275
DOI: 10.1038/sj.onc.1201983

Genes

MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9715275-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Duplication and overexpression of the mutant allele of the MET proto-oncogene in multiple hereditary papillary renal cell tumours.PMID 9715275Read ↗

Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas.Semantic proximity Read ↗

Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas.Semantic proximity Read ↗

Papillary renal cell carcinoma: analysis of germline mutations in the MET proto-oncogene in a clinic-based population.Semantic proximity Read ↗

EARLY ONSET HEREDITARY PAPILLARY RENAL CARCINOMA: GERMLINE MISSENSE MUTATIONS IN THE TYROSINE KINASE DOMAIN OF THE MET PROTO-ONCOGENESemantic proximity Read ↗

Two North American families with hereditary papillary renal carcinoma and identical novel mutations in the MET proto-oncogene.Semantic proximity Read ↗

Novel mutation in the ATP-binding site of theMET oncogene tyrosine kinase in a HPRCC familySemantic proximity Read ↗

Germline and somatic c-met mutations in multifocal/bilateral and sporadic papillary renal carcinomas of selected patients.Semantic proximity Read ↗

Hereditary papillary renal carcinoma type I.Semantic proximity Read ↗

Germline large genomic alterations on 7q in patients with multiple primary cancers.Semantic proximity Read ↗

Common pattern of unusual chromosome abnormalities in hereditary papillary renal carcinoma.Semantic proximity Read ↗

Trisomy 7 and 17 mark papillary renal cell tumours irrespectively of variation of the phenotype.Semantic proximity Read ↗

Evaluation of the tyrosine kinase domain of the Met proto-oncogene in sporadic ovarian carcinomas*.Semantic proximity Read ↗

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