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Article

Novel mutation in the ATP-binding site of theMET oncogene tyrosine kinase in a HPRCC family

27 Aug 1999

Abstract excerpt

Germline mutations in the tyrosine-kinase domain of the MET proto-oncogene were found in patients suffering from the hereditary predisposition to develop multiple papillary renal-cell carcinomas (hereditary PRCC, HPRCC). PRCCs are often multiple and bilateral even in patients without a family history. We analyzed the germline of patients carrying multiple or single papillary tumors with and without family...

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Identifiers

PMID: 10417759
DOI: 10.1002/(sici)1097-0215(19990827)82:5<640::aid-ijc4>3.0.co;2-6

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Source receipt: pubmed, retrieved 7 Sept 2026.

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