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Article

Mutational analysis of PDGFR-RAS/MAPK pathway activation in childhood medulloblastoma.

European journal of cancer (Oxford, England : 1990) - 1 Mar 2006

Gilbertson Richard J, Langdon Jaqueline A, Hollander Andrew, Hernan Roberto, Hogg Twala L, Gajjar Amar, Fuller Christine, Clifford Steven C

Abstract excerpt

Aberrant signalling via platelet derived growth factor receptors (PDGFRs) and the RAS/MAPK pathway has been implicated in the development of medulloblastoma, the most common malignant brain tumour in childhood. To determine whether genetic mechanisms play a role in the activation of PDGFR-RAS/MAPK signalling in medulloblastoma, we performed a direct sequence analysis of the established mutational "hotspots" of...

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Share to Cerebellar Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MAP Kinase Signaling System

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Share to Mitogen-Activated Protein Kinases

Share to Polymorphism, Restriction Fragment Length

Share to Receptor, Platelet-Derived Growth Factor alpha

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Source

Identifiers

PMID: 16434186
DOI: 10.1016/j.ejca.2005.11.023

Genes

PDGFRA
BRAF
HRAS
KRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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