Article
Japanese individuals do not harbor the T594M mutation but do have the P592S mutation in the C-terminus of the beta-subunit of the epithelial sodium channel: the Ohasama study.
Journal of hypertension - 1 Jul 2000
Matsubara M, Ohkubo T, Michimata M, Hozawa A, Ishikawa K, Katsuya T, Nagai K, Tsuji I, Higaki J, Araki T, Satoh H, Hisamichi S, Ito S, Ogihara T, Imai Y
Abstract excerpt
OBJECTIVE: To assess the implications of polymorphisms of the amiloride-sensitive epithelial sodium channel in essential hypertension in the Japanese population by determining the incidence of the T594M mutation in the , subunit of the epithelial sodium channel, and by screening the C-terminus of the epithelial sodium channel. METHODS: Single-strand confirmational polymorphism (SSCP) analysis using two sets of...
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