Article
Infrequent occurrence of single mutations in topoisomerase IV and DNA gyrase genes among US levofloxacin-susceptible clinical isolates of Streptococcus pneumoniae from nine institutions (1999-2003).
The Journal of antimicrobial chemotherapy - 1 Mar 2006
Davies Todd A, Yee Y Cheung, Goldschmidt Raul, Bush Karen, Sahm Daniel F, Evangelista Alan
Abstract excerpt
OBJECTIVES: Prevalence of single quinolone-resistance determining region (QRDR) mutations in Streptococcus pneumoniae was studied from nine institutions over 5 years to track the incidence of single QRDR mutations. METHODS: All 1106 levofloxacin-susceptible pneumococci (MICs < or = 2.0 mg/L) iden...
Topics
- Anti-Bacterial Agents
- DNA Gyrase
- DNA Topoisomerase IV
- Drug Resistance, Bacterial
- Gene Expression Regulation, Bacterial
- Gene Expression Regulation, Enzymologic
- Levofloxacin
- Microbial Sensitivity Tests
- Mutation
- Ofloxacin
- Pneumococcal Infections
- Streptococcus pneumoniae