Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular characterization of fluoroquinolone resistance in invasive clinical isolates of Streptococcus pneumoniae susceptible to delafloxacin.

The Journal of antimicrobial chemotherapy - 3 Oct 2025

Cercenado Emilia, Marín Mercedes, Iglesias Manuel, Jiménez Laura, Pérez-Abeledo Marta, Sanz Juan Carlos

Abstract excerpt

BACKGROUND: Delafloxacin is a dual-targeting fluoroquinolone against topoisomerase IV and DNA gyrase that could decrease resistance selection by diminishing the likelihood of multiple mutational events in both enzymes. OBJECTIVES: To determine the activity of delafloxacin against invasive Streptococcus pneumoniae isolates resistant to levofloxacin (LEV-R), compare delafloxacin MICs for LEV-R isolates with those...

Read the complete abstract on PubMed

Topics

Streptococcus pneumoniae
Fluoroquinolones
Anti-Bacterial Agents
Microbial Sensitivity Tests
Humans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Drug Resistance, Bacterial

Pneumococcal Infections

DNA Gyrase

DNA Topoisomerase IV

Levofloxacin

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 40836876
DOI: 10.1093/jac/dkaf308
PMCID: PMC12581615

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular characterization of fluoroquinolone resistance in invasive clinical isolates of Streptococcus pneumoniae susceptible to delafloxacin.PMID 40836876Read ↗

Fluoroquinolone resistance in Streptococcus pneumoniae isolates in Germany from 2004-2005 to 2014-2015.Semantic proximity Read ↗

Detection of Delafloxacin Resistance Mechanisms in Multidrug-Resistant Klebsiella pneumoniaeSemantic proximity Read ↗

Molecular characterization of increasing fluoroquinolone resistance in Streptococcus pneumoniae isolates in Canada, 1997 to 2005.Semantic proximity Read ↗

Molecular Characterization of Italian Isolates of Fluoroquinolone-Resistant Streptococcus agalactiae and Relationships with Chloramphenicol Resistance.Semantic proximity Read ↗

Analysis of molecular mechanisms of delafloxacin resistance in Escherichia coli.Semantic proximity Read ↗

Molecular characterization of 8-methoxyfluoroquinolone resistance in a clinical isolate of methicillin-resistant Staphylococcus aureus.Semantic proximity Read ↗

Phenotypic and genotypic analysis of levofloxacin-resistant clinical isolates of Streptococcus pneumoniae collected in 13 countries during 1999-2000.Semantic proximity Read ↗

Worldwide incidence, molecular epidemiology and mutations implicated in fluoroquinolone-resistant Streptococcus pneumoniae: data from the global PROTEKT surveillance programme.Semantic proximity Read ↗

Molecular characterisation of the quinolone resistance-determining regions (QRDR) including gyrA, gyrB, parC and parE genes in Streptococcus pneumoniae.Semantic proximity Read ↗

Are fluoroquinolone-susceptible isolates of Streptococcus pneumoniae really susceptible? A comparison of resistance mechanisms in Canadian isolates from 1997 and 2003.Semantic proximity Read ↗

Incidence and epidemiology of levofloxacin resistance in Streptococcus pneumoniae: experience from a tertiary referral hospital in England.Semantic proximity Read ↗

The molecular epidemiology of Streptococcus pneumoniae with quinolone resistance mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.