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Article

'Supermutators' found amongst highly levofloxacin-resistant E. coli isolates: a rapid protocol for the detection of mutation sites.

Emerging microbes & infections - 1 Jan 2015

Zayed Ahmed Abdel-Fattah, Essam Tamer Mohamed, Hashem Abdel-Gawad Mohamed, El-Tayeb Ossama Mohamed

Abstract excerpt

Fluoroquinolone resistance is gradually acquired through several mechanisms. In particular, chromosomal mutations in the genes encoding topoisomerases II and IV and increased expression of the multidrug efflux pump AcrAB-TolC are the most common mechanisms. In this study, multiplex polymerase chain reaction (PCR) protocols were designed for high-throughput sequencing of the quinolone resistance determining...

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Source

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Identifiers

PMID: 26038761
DOI: 10.1038/emi.2015.4
PMCID: PMC4317672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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