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Article

Prevalence of first-step mutants among levofloxacin-susceptible isolates of Streptococcus pneumoniae in north Lebanon.

Journal of chemotherapy (Florence, Italy) - 1 Dec 2013

Dabboussi Fouad, Allouche Saria, Mallat Hassan, Hamze Monzer

Abstract excerpt

Resistance of Streptococcus pneumoniae to fluoroquinolones arises by stepwise accumulation of spontaneous point mutations in the quinolone-resistance determining regions (QRDRs). Fluoroquinolones treatment of infections caused by first-step mutants (pre-resistant) can lead to the selection of resistant isolates, resulting in treatment failure. First-step mutants cannot however be reliably detected by routine...

Topics

Blood
Drug Resistance, Bacterial
Ear
Eye
Fluoroquinolones
Humans
Lebanon
Levofloxacin
Lung
Microbial Sensitivity Tests
Mutation
Nose

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pneumococcal Infections

Prevalence

Streptococcus pneumoniae

Source

Identifiers

PMID: 24091419
DOI: 10.1179/1973947813Y.0000000101

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-24091419-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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