Proteome survey reveals modularity of the yeast cell machinery.

doi:10.1038/nature04532

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Article

Proteome survey reveals modularity of the yeast cell machinery.

Nature - 30 Mar 2006

Gavin Anne-Claude, Aloy Patrick, Grandi Paola, Krause Roland, Boesche Markus, Marzioch Martina, Rau Christina, Jensen Lars Juhl, Bastuck Sonja, Dümpelfeld Birgit, Edelmann Angela, Heurtier Marie-Anne, Hoffman Verena, Hoefert Christian, Klein Karin, Hudak Manuela, Michon Anne-Marie, Schelder Malgorzata, Schirle Markus, Remor Marita, Rudi Tatjana, Hooper Sean, Bauer Andreas, Bouwmeester Tewis, Casari Georg, Drewes Gerard, Neubauer Gitte, Rick Jens M, Kuster Bernhard, Bork Peer, Russell Robert B, Superti-Furga Giulio

Abstract excerpt

Protein complexes are key molecular entities that integrate multiple gene products to perform cellular functions. Here we report the first genome-wide screen for complexes in an organism, budding yeast, using affinity purification and mass spectrometry. Through systematic tagging of open reading frames (ORFs), the majority of complexes were purified several times, suggesting screen saturation. The richness of the...

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PMID: 16429126
DOI: 10.1038/nature04532

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