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Article

Interaction network containing conserved and essential protein complexes in Escherichia coli.

Nature - 3 Feb 2005

Butland Gareth, Peregrín-Alvarez José Manuel, Li Joyce, Yang Wehong, Yang Xiaochun, Canadien Veronica, Starostine Andrei, Richards Dawn, Beattie Bryan, Krogan Nevan, Davey Michael, Parkinson John, Greenblatt Jack, Emili Andrew

Abstract excerpt

Proteins often function as components of multi-subunit complexes. Despite its long history as a model organism, no large-scale analysis of protein complexes in Escherichia coli has yet been reported. To this end, we have targeted DNA cassettes into the E. coli chromosome to create carboxy-terminal, affinity-tagged alleles of 1,000 open reading frames (approximately 23% of the genome). A total of 857 proteins,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15690043
DOI: 10.1038/nature03239

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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