Article

The prophase oocyte nucleus is a homeostatic G-actin buffer

2020-10-30

Abstract excerpt

Formation of healthy mammalian eggs from oocytes requires specialised F-actin structures. F-actin disruption produces aneuploid eggs, which are a leading cause of human embryo deaths, genetic disorders, and infertility. We found that oocytes regulate F-actin organisation and function by promptly transferring excess monomeric G-actin from the cytoplasm to the nucleus. Inside healthy oocyte nuclei, transferred monom...

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Literature Corpus work: 33ab3bcb-7b64-5ee6-a807-57a2c246135d
DOI: 10.1101/2020.10.30.353961

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