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Article

Identification and Characterization of RHOA-Interacting Proteins in Bovine Spermatozoa1

10 Oct 2007

Abstract excerpt

In somatic cells, RHOA mediates actin dynamics through a GNA13-mediated signaling cascade involving RHO kinase (ROCK), LIM kinase (LIMK), and cofilin. RHOA can be negatively regulated by protein kinase A (PRKA), and it interacts with members of the A-kinase anchoring (AKAP) family via intermediary proteins. In spermatozoa, actin polymerization precedes the acrosome reaction, which is necessary for normal...

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PMID: 17928627
DOI: 10.1095/biolreprod.107.062943

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