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Polarity and cell division orientation in the cleavage embryo: from worm to human

9 Dec 2015

Abstract excerpt

Cleavage is a period after fertilization, when a 1-cell embryo starts developing into a multicellular organism. Due to a series of mitotic divisions, the large volume of a fertilized egg is divided into numerous smaller, nucleated cells-blastomeres. Embryos of different phyla divide according to different patterns, but molecular mechanism of these early divisions remains surprisingly conserved. In the present...

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PMID: 26660321
DOI: 10.1093/molehr/gav068

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